Often Appraise patients, specifically when initiating and titrating dose and when given concomitantly with other drugs that depress respiration; alternatively, consider use of non-opioid analgesics in these patients
For oral drugs where reductions in bioavailability may possibly cause clinically significant effects on its basic safety or efficacy, separate administration of ferric maltol from these drugs. Duration of separation may well rely upon the absorption with the medication concomitantly administered (eg, time to peak concentration, whether or not the drug is a direct or prolonged release merchandise).
bremelanotide will lower the level or effect of fentanyl by Other (see remark). Steer clear of or Use Alternate Drug. Bremelanotide could sluggish gastric emptying and potentially lessens the rate and extent of absorption of concomitantly administered oral medications.
fentanyl will enhance the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
If coadministration of CYP3A4 inhibitors with fentanyl is critical, watch patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until stable drug effects are attained.
Therapy may well improve frequency of seizures in patients with seizure disorders and in other clinical configurations connected with seizures; monitor patients for worsened seizure control during therapy
Don't Chunk or chew the lozenge, and try not to complete it too quickly. It must take about quarter-hour to melt.
duvelisib will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration with duvelisib will increase AUC of the sensitive CYP3A4 substrate which may improve the risk of toxicities of such drugs.
fentanyl will lessen the level or effect of prasugrel by inhibition of GI absorption. Applies only to oral type of both agents. Modify Therapy/Keep an eye on Intently. Coadministration of opioid agonists delay and reduce the absorption of prasugrel?
methylene blue and fentanyl equally raise serotonin levels. Avoid or Use Alternate Drug. If drug combination has to be administered, keep an eye on for proof of serotonergic or opioid-related toxicities
If coadministration of CYP3A4 inhibitors with fentanyl is necessary, check patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until eventually stable drug effects are attained.
glycerol phenylbutyrate will reduce the level or effect of fentanyl by fentanyl overdose symptoms and duration affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Glycerol phenylbutyrate is actually a weak inducer of CYP3A4. Observe for decreased efficacy of CYP3A4 substrates that have a slender therapeutic index.
fentanyl will boost the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Decreased nightly dose of lemborexant advisable if coadministered with weak CYP3A4 inhibitors. See drug monograph for certain dosage modification.
B: Could be acceptable. Either animal reports show no risk but human research not out there or animal scientific studies showed minimal risks and human research performed and showed no risk.